Pharmacological Modulation of the Ca2+/cAMP/Adenosine Signaling in Cardiac Cells as a New Cardioprotective Strategy to Reduce Severe Arrhythmias in Myocardial Infarction.

Acute myocardial infarction (AMI) is the main cause of morbidity and mortality worldwide and is characterized by severe and fatal arrhythmias induced by cardiac ischemia/reperfusion (CIR). However, the molecular mechanisms involved in these arrhythmias are still little understood. To investigate the cardioprotective role of the cardiac Ca2+/cAMP/adenosine signaling pathway in AMI, L-type Ca2+ channels (LTCC) were blocked with either nifedipine (NIF) or verapamil (VER), with or without A1-adenosine (ADO), receptors (A1R), antagonist (DPCPX), or cAMP efflux blocker probenecid (PROB), and the incidence of ventricular arrhythmias (VA), atrioventricular block (AVB), and lethality (LET) induced by CIR in rats was evaluated. VA, AVB and LET incidences were evaluated by ECG analysis and compared between control (CIR group) and intravenously treated 5 min before CIR with NIF 1, 10, and 30 mg/kg and VER 1 mg/kg in the presence or absence of PROB 100 mg/kg or DPCPX 100 µg/kg. The serum levels of cardiac injury biomarkers total creatine kinase (CK) and CK-MB were quantified. Both NIF and VER treatment were able to attenuate cardiac arrhythmias caused by CIR; however, these antiarrhythmic effects were abolished by pretreatment with PROB and DPCPX. The total serum CK and CK-MB were similar in all groups. These results indicate that the pharmacological modulation of Ca2+/cAMP/ADO in cardiac cells by means of attenuation of Ca2+ influx via LTCC and the activation of A1R by endogenous ADO could be a promising therapeutic strategy to reduce the incidence of severe and fatal arrhythmias caused by AMI in humans.

Pharmacological Modulation by Low Molecular Weight Heparin of Purinergic Signaling in Cardiac Cells Prevents Arrhythmia and Lethality Induced by Myocardial Infarction.

BACKGROUND: Although several studies suggest that heparins prevent arrhythmias caused by acute myocardial infarction (AMI), the molecular mechanisms involved remain unclear. To investigate the involvement of pharmacological modulation of adenosine (ADO) signaling in cardiac cells by a low-molecular weight heparin (enoxaparin; ENOX) used in AMI therapy, the effects of ENOX on the incidences of ventricular arrhythmias (VA), atrioventricular block (AVB), and lethality (LET) induced by cardiac ischemia and reperfusion (CIR) were evaluated, with or without ADO signaling blockers. METHODS: To induce CIR, adult male Wistar rats were anesthetized and subjected to CIR. Electrocardiogram (ECG) analysis was used to evaluate CIR-induced VA, AVB, and LET incidence, after treatment with ENOX. ENOX effects were evaluated in the absence or presence of an ADO A1-receptor antagonist (DPCPX) and/or an inhibitor of ABC transporter-mediated cAMP efflux (probenecid, PROB). RESULTS: VA incidence was similar between ENOX-treated (66%) and control rats (83%), but AVB (from 83% to 33%) and LET (from 75% to 25%) incidences were significantly lower in rats treated with ENOX. These cardioprotective effects were blocked by either PROB or DPCPX. CONCLUSION: These results indicate that ENOX was effective in preventing severe and lethal arrhythmias induced by CIR due to pharmacological modulation of ADO signaling in cardiac cells, suggesting that this cardioprotective strategy could be promising in AMI therapy.

First results from the releases of Cinereous Vultures (Aegypiusmonachus) aiming at re-introducing the species in Bulgaria - the start of the establishment phase 2018-2022.

The current work presents the preliminary results of the Cinereous Vulture (Aegypiusmonachus) releases in the Balkan Mountains in 2018-2022, aiming at the species re-introduction in Bulgaria, where it was listed as locally extinct since 1985. The first imports and releases of Cinereous Vultures in Bulgaria started in 2018. Until mid-2022, 72 individuals were released in the Eastern Balkan Mountains (Kotlenska Planina SPA and Sinite Kamani Nature Park) and Vrachanski Balkan Nature Park. Of them, 63 immatures imported from Spain were released from aviaries and nine juveniles captive-bred in European zoos were released by hacking (fledging from an artificial nest). We compared the success in survival and establishment between the different release sites and methods used to adjust the ongoing technics and tactics and to support knowledge improvement for future similar projects. From the nine Cinereous Vultures released by hacking, the results were as follows: 1.00 fledging success, but only 0.22 survival in the first six months - combined period of acclimation, first migration and the first winter. All survivors from that period reached maturity into the wild, but all emigrated from the release site and settled elsewhere. Of the 63 individuals released by aviaries, 32 individuals were released in the Eastern Balkan Mountains (18 individuals are still alive - 0.56 survival; 14 individuals settled in the area, which accounts for 0.44 of all released birds and 0.78 of the survivors). Thirty-one individuals were released in Vrachanski Balkan Nature Park (23 individuals are still alive - 0.74 survival; 22 individuals settled in the area - 0.71 of all released birds and 0.96 of the survivors). Based only on aviary method comparison, the settling of the individuals in the release area was alike in the two sites. However, the Vrachanski Balkan Nature Park performed better in survival - both in acclimation and establishment periods. While comparing the release methods - hacking and release from the aviary - the following results were observed: the survival rate during acclimation was 0.86. Due to more considerable losses during the first migration and dispersal in the individuals released by hacking, the survival rate of 0.22 was significantly lower compared to 0.73 for the birds released from the aviary. Additionally, in both methods, a similar pattern in the first winter and spring migration dispersal was observed. Although the survival was equal in the released-by-hacking or aviary birds after the first year onwards, it is essential to note that the emigration of the hacked birds from the release site was 1.00. In comparison, the birds released from aviaries largely remained and settled in the release area (> 0.77 of the survivors). The cost of release and related acclimation, settling, dispersal and the first winter was the greatest: 0.12-0.17 per period, or cumulatively, it was about 0.27. Survival increased and stabilised to > 0.90 after the first year in the wild and reached nearly 1.00 after two years in the wild onwards. Two distinct nuclei of the Cinereous Vulture were established along the Balkan Mountains - the Eastern Balkan Mountains with 18-23 individuals and four formed pairs using a territory of about 642.74 km2 - 95% home range and 85.72 km2 - 50% core area with center being the town of Kotel; and Vrachanski Balkan Nature Park with present 23-29 individuals, of which 2-3 pairs formed so far, using a territory of about 1,143.66 km2 - 95% home range and 22.89 km2 - 50% core area with center being the village of Zgorigrad. The species readily accepted breeding in artificial nest platforms built by professional arborists on different tree species - oak, beech, sycamore and pine. The only naturally built nests were on the ground (n = 2) (unsuccessful) and in Scots Pine (n = 1) (successful). In 2021 and 2022, in each of the two sites, the first successful reproductions were recorded, which marked the return of the Cinereous Vulture as breeding species - 28 years after the last occasional record of a single breeding pair in the country and 36 years after it was officially listed as locally extinct in Bulgaria.

Amino Acid Complexes of Zirconium in a Carbon Composite for the Efficient Removal of Fluoride Ions from Water.

Amino acid complexes of zirconia represent an entirely new class of materials that were synthesized and studied for the first time for the decontamination of fluoride ion containing aqueous solutions. Glutamic and aspartic acid complexes of zirconia assembled with thin carbon (stacked graphene oxide) platelets deriving from graphite oxide (GO) were synthesized by a two-step method to prepare adsorbents. The characterization of the complexes was carried out using infrared spectroscopy to determine the functional groups and the types of interaction between the composites and fluoride ions. To reveal the mechanisms and extent of adsorption, two types of batch adsorption measurements were performed: (i) varying equilibrium fluoride ion concentrations to construct adsorption isotherms at pH = 7 in the absence of added electrolytes and (ii) using fixed initial fluoride ion concentrations (10 mg/L) with a variation of either the pH or the concentration of a series of salts that potentially interfere with adsorption. The experimental adsorption isotherms were fitted by three different theoretical isotherm equations, and they are described most appropriately by the two-site Langmuir model for both adsorbents. The adsorption capacities of Zr-glutamic acid-graphite oxide and Zr-aspartic acid-graphite oxide are 105.3 and 101.0 mg/g, respectively. We found that two distinct binding modes are combined in the Zr-amino acid complexes: at low solution concentrations, F- ions are preferentially adsorbed by coordinating to the surface Zr species up to a capacity of ca. 10 mg/g. At higher concentrations, however, large amounts of fluoride ions may undergo anion exchange processes and physisorption may occur on the positively charged ammonium moieties of the interfacially bound amino acid molecules. The high adsorption capacity and affinity of the studied dicarboxylate-type amino acids demonstrate that amino acid complexes of zirconia are highly variable materials for the safe and efficient capture of strong Lewis base-type ions such as fluoride.

Immediate Implant With Provisionalization and Soft Tissue Grafting After 4-Year Follow-Up.

INTRODUCTION: This paper presents a case report of immediate implant placement (IIP) with a provisionalization technique to restore function and esthetics with follow-up after 4 years. CASE PRESENTATION: Minimally traumatic extraction was performed with IIP, soft-tissue grafting, and immediate provisional crown. Six months after optimal healing, the patient was submitted to an esthetic restorative work through veneers in lithium disilicate. Fourteen-month and 4-year follow-up visits revealed stability of the peri-implant soft-tissues with peri-implant health status, with the evaluation of the pink and white esthetic score, yielding to mean scores, respectively, in 14 months of 11.62 ± 2.07 (pink esthetic score [PES]) and 18.25 ± 1.46 (PES/white esthetic score [WES]) and in 4 years of 11.0 ± 1.32 (PES) and 17.62 ± 0.65 (PES/WES). Intraoral digital radiographs showed minimal crestal bone level changes throughout the follow-up period. Thus, IIP is a sensitive technique procedure, and a 3D implant position is crucial for success. CONCLUSION: Immediate implant with grafting to fill the gap and soft tissue augmentation led to less horizontal changes and stable mucosal margin, and immediate provisionalization helped to maintain soft tissue architecture, and proper case selection is key for clinical success.

Phase behavior of a binary mixture of patchy colloids: Effect of particle size and gravity.

We study theoretically the effect of size difference and that of gravity in the phase behavior of a binary mixture of patchy particles. The species, 2A and 3B, have two A and three B patches, respectively, and only bonds between patches A and B (AB bonds) are allowed. This model describes colloidal systems where the aggregation of particles (3B) is mediated and controlled by a second species, the linkers (2A) to which they bind strongly. Thermodynamic calculations are performed using Wertheim's perturbation theory with a hard sphere reference term that accounts for the difference in the size of the two species. Percolation lines are determined employing a generalized Flory-Stockmayer theory, and the effects of gravity are included through a local density approximation. The bulk phase diagrams are calculated, and all the stacking sequences generated in the presence of gravity are determined and classified in a stacking diagram. The relative size of the particles can be used to control the phase behavior of the mixture. An increase in the size of particles 3B, relative to the size of the linkers 2A, is found to promote mixing while keeping the percolating structures and, in certain cases, leads to changes in the stacking sequence under gravity.

Differential survival throughout the full annual cycle of a migratory bird presents a life-history trade-off.

Long-distance migrations are among the most physically demanding feats animals perform. Understanding the potential costs and benefits of such behaviour is a fundamental question in ecology and evolution. A hypothetical cost of migration should be outweighed by higher productivity and/or higher annual survival, but few studies on migratory species have been able to directly quantify patterns of survival throughout the full annual cycle and across the majority of a species' range. Here, we use telemetry data from 220 migratory Egyptian vultures Neophron percnopterus, tracked for 3,186 bird months and across approximately 70% of the species' global distribution, to test for differences in survival throughout the annual cycle. We estimated monthly survival probability relative to migration and latitude using a multi-event capture-recapture model in a Bayesian framework that accounted for age, origin, subpopulation and the uncertainty of classifying fates from tracking data. We found lower survival during migration compared to stationary periods (ß = -0.816; 95% credible interval: -1.290 to -0.318) and higher survival on non-breeding grounds at southern latitudes (<25°N; ß = 0.664; 0.076-1.319) compared to on breeding grounds. Survival was also higher for individuals originating from Western Europe (ß = 0.664; 0.110-1.330) as compared to further east in Europe and Asia, and improved with age (ß = 0.030; 0.020-0.042). Anthropogenic mortalities accounted for half of the mortalities with a known cause and occurred mainly in northern latitudes. Many juveniles drowned in the Mediterranean Sea on their first autumn migration while there were few confirmed mortalities in the Sahara Desert, indicating that migration barriers are likely species-specific. Our study advances the understanding of important fitness trade-offs associated with long-distance migration. We conclude that there is lower survival associated with migration, but that this may be offset by higher non-breeding survival at lower latitudes. We found more human-caused mortality farther north, and suggest that increasing anthropogenic mortality could disrupt the delicate migration trade-off balance. Research to investigate further potential benefits of migration (e.g. differential productivity across latitudes) could clarify how migration evolved and how migrants may persist in a rapidly changing world.

Two-Step Triethylamine-Based Synthesis of MgO Nanoparticles and Their Antibacterial Effect against Pathogenic Bacteria.

Magnesium oxide nanoparticles (MgO NPs) were obtained by the calcination of precursor microparticles (PM) synthesized by a novel triethylamine-based precipitation method. Scanning electron microscopy (SEM) revealed a mean size of 120 nm for the MgO NPs. The results of the characterizations for MgO NPs support the suggestion that our material has the capacity to attack, and have an antibacterial effect against, Gram-negative and Gram-positive bacteria strains. The ability of the MgO NPs to produce reactive oxygen species (ROS), such as superoxide anion radicals (O2•-) or hydrogen peroxide (H2O2), was demonstrated by the corresponding quantitative assays. The MgO antibacterial activity was evaluated against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria, with minimum inhibitory concentrations (MICs) of 250 and 500 ppm on the microdilution assays, respectively. Structural changes in the bacteria, such as membrane collapse; surface changes, such as vesicular formation; and changes in the longitudinal and horizontal sizes, as well as the circumference, were observed using atomic force microscopy (AFM). The lipidic peroxidation of the bacterial membranes was quantified, and finally, a bactericidal mechanism for the MgO NPs was also proposed.

Estudios latinoamericanos de ocio: américa latina como horizonte / Latin american leisure studies: latin america as a horizon

El texto hace parte del informe final de la investigación "El Ocio Abigarrado. Apuntes para una lectura en Contextos de Pluriversidad. Lecturas desde las Prácticas Lúdicas Populares y Tradicionales", realizada en el Programa de Pos-Doctorado en Estudios Culturales del Programa Avanzado de Cultura Contemporánea de la Facultad de Letras de la Universidad Federal de Rio de Janeiro. Corresponde a una investigación documental, cuyo propósito fue presentar algunos bosquejos que posibilitaran, más allá de referencias totalizantes, una -entre otras- capaz de reconocer la complejidad como condición constituyente de nuestras sociedades latinoamericanas. Para ello se realizó un análisis de tres libros colectivos hechos con autores de la región, sobre la temática del ocio, la recreación y el tiempo libre, buscando precisar las principales tendencias del campo en la región.

The text is part of the final report of the investigation "The Variegated Leisure. Notes for a reading in Pluriversity Contexts. Readings from the Popular and Traditional Playful Practices ", carried out in the Post-Doctorate Program in Cultural Studies of the Advanced Program of Contemporary Culture of the Faculty of Letters of the Federal University of Rio de Janeiro. It corresponds to a documentary investigation, whose purpose was to present some sketches that will allow, beyond totalizing references, one -among others- capable of recognizing complexity as a constituent condition of our Latin American societies. For this, an analysis of three collective books made with authors from the region, on the theme of leisure, recreation and free time, was carried out, seeking to specify the main trends of the field in the region.

Cardioprotective effects of pharmacological blockade of the mitochondrial calcium uniporter on myocardial ischemia-reperfusion injury.

PURPOSE: To evaluate whether the attenuation of mitochondrial Ca2+ overload produced by pharmacological blockade of mitochondrial Ca2+ uniporter (MCU) protects the myocardium against injuries caused by cardiac ischemia and reperfusion (CIR). METHODS: CIR was induced in adult male Wistar rats (300-350 g) by occlusion of the left anterior descendent coronary artery (10 min), followed by reperfusion (120 min). Rats were treated with different doses of MCU blocker ruthenium red (RuR), administered 5 min before ischemia or reperfusion. RESULTS: In untreated rats, the incidences of ventricular arrhythmias (VA), atrioventricular block (AVB) and the lethality (LET) induced by CIR were 85%, 79% and 70%, respectively. In rats treated with RuR before ischemia, the incidences of VA, AVB and LET were significantly reduced to 62%, 25% and 25%, respectively. In rats treated with RuR after ischemia, the incidences of VA, AVB and LET were significantly reduced to 50%, 25% and 25%, respectively. CONCLUSION: The significant reduction of the incidence of CIR-induced VA, AVB and LET produced by the treatment with RuR indicates that the attenuation of mitochondrial Ca2+ overload produced by pharmacological blockade of MCU can protect the myocardium against injuries caused by CIR.

Infection of Henneguya sp. on the gills of Metynnis lippincottianus from Curiaú River, in eastern Amazon region (Brazil).

Infection of fish gills by Henneguya causes greater contact between the secondary gill lamellae, thereby giving rise to decreased absorption surface area at the end of the filaments. This ectoparasite can cause damages on the gills infected fish. In the present study, fresh gills of Metynnis lippincottianus were analyzed using optical microscopy techniques. The myxoporean Henneguya sp. was found to be infecting 80% of the gills of this host fish. Presence of this parasite caused hyperplasia and fusion of the gill lamellae, but without inflammation in the parasitized organ.

O tempo eróptico: algumas notas sobre o mal-estar do silêncio e as respostas na contemporaneidade / The eroptic time: some notes on the malaise of silence and the answers in contemporary times / El tiempo eróptico: algunas notas sobre el malestar del silencio y las respuestas en los tiempos contemporáneos / Le temps eroptique: quelques notes sur le malaise du silence et les réponses à l'époque contemporaine

Este artigo propõe olhar para o sofrimento psíquico contemporâneo. Para isso, o percurso feito pela psicopatologia desde o século XVII é revisitado, nele se destacando o impacto promovido por Freud, que passou da ausculta para a escuta das vozes falando dos conflitos neuróticos que desafiavam a anatomia e a fisiologia médica. A psicanálise se dá na relação com a cultura. Como pensar a psicopatologia hoje? Na clínica psicanalítica atual, a infelicidade neurótica divide espaço com outros sofrimentos, como, por exemplo, as várias formas de adição química, comportamentos workaholic, vício digital, descontrole no uso dos cartões de crédito, transtornos alimentares e manifestações psicossomáticas, além de respostas erópticas em uma modalidade selfie do existir. Propõe-se que um dos articuladores dessas ocorrências possa ser um estado de mal-estar do silêncio, próprio da contemporaneidade, que produz ruídos para ensurdecer a experiência do estar-em-si.

This article proposes to look at contemporary psychological suffering. To this end, the path taken by psychopathology since the 17th century is revisited, highlighting the impact promoted by Freud, who went from auscultation to listening to the voices that spoke of neurotic conflicts that defied anatomy and medical physiology. Psychoanalysis takes place in relation to culture. How to think about psychopathology today? In the current psychoanalytic clinic, neurotic unhappiness shares space with other sufferings such as the various forms of chemical addiction, workaholic behaviors, digital addiction, uncontrolled use of credit cards, eating disorders and psychosomatic manifestations in addition to eroptic responses in a selfie mode of existence. It is proposed that one of the articulators of these occurrences may be a state of malaise of silence, typical of contemporary times, which produces noises to deafen the experience of being-in-itself.

Este artículo propone mirar el sufrimiento psicológico contemporáneo. Con este fin, se revisa el camino tomado por la psicopatologia desde el siglo XVII, destacando el impacto promovido por Freud, que pasó de la auscultación a escuchar las voces que hablaban de conflictos neuróticos que desafiaban la anatomía y la fisiología médica. El psicoanálisis tiene lugar en relación con la cultura. ¿Cómo pensar hoy en psicopatología? En la clínica psicoanalítica actual, la infelicidad neurótica comparte espacio con otros sufrimientos, como las diversas formas de adicción química, comportamientos de adicción al trabajo, adicción digital, uso descontrolado de tarjetas de crédito, trastornos alimentarios y manifestaciones psicosomáticas, además de respuestas erópticas en un modo selfie de la existencia. Se propone que uno de los articuladores de estos acontecimientos puede ser un estado de malestar del silencio, típico de los tiempos contemporáneos, que produce ruidos para ensordecer la experiencia del ser en sí mismo.

Cet article propose d'examiner la souffrance psychologique contemporaine. À cette fin, le chemin emprunté par la psychopathologie depuis le XVIIe siècle est revisité, mettant en évidence l'impact promu par Freud, qui est passé de l'auscultation à l'écoute des voix qui parlaient de conflits névrotiques qui défiaient l'anatomie et la physiologie médicale. La psychanalyse a lieu par rapport à la culture. Comment penser la psychopathologie aujourd'hui ? Dans la clinique psychanalytique actuelle, le malheur névrotique partage l'espace avec d'autres souffrances telles que les diverses formes de dépendance chimique, les comportements de bourreau de travail, la dépendance numérique, l'utilisation incontrôlée de cartes de crédit, les troubles de l'alimentation et les manifestations psychosomatiques en plus des réponses éroptiques en mode selfie de la existence. Il est proposé que l'un des articula-teurs de ces événements puisse être un état de malaise du silence, typique de l'époque contemporaine, qui produit des bruits pour assourdir l'expérience d'être en soi.

A survey of talent identification and development processes in the youth academies of professional soccer clubs from around the world.

Talent identification (TID) and development (TDE) are large fields in professional soccer and in science. However,  TID and TDE processes in youth academies have not been assessed in detail. As such, our aim was to survey professional clubs from around the world about their youth academy TID and TDE processes, with 29 clubs responding to the survey. TID and TDE processes changed as a function of player age. TID processes involved finding the best players locally and regionally, but for older players the search widened to nationally and internationally for the needs of the first team. Clubs used a multidisciplinary approach to TID, but more so with older players. Median number of academy players was 80, 100, and 66 players at 8-11 years, 12-16 years, and 17-21 years, respectively. Annual player turnover in the most recent season (selections/de-selections) was 29% across all age groups, with competition from other clubs cited as a limitation to TID. TDE processes involved weekly matches and 3-5 training sessions per week led by experienced, well-qualified coaches, with most clubs providing players with academic education, residency and transportation services. Our findings extend previous research assessing professional soccer youth academy TID and TDE processes by quantifying worldwide practices.

Mapa de Evidência: efetividade clínica da Fitoterapia e Plantas Medicinais para Cicatrização e Doenças Agudas / Evidence Map: clinical effectiveness of Medicinal Plants and Phytotherapy for Wound Healing and Acute Diseases / Mapa de Evidencia: efetividad clínica de las Plantas Medicinales y Fitoterapia para Cicatrización y Enfermedades Agudas

O mapa apresenta uma visão geral das evidências sobre os efeitos das Plantas Medicinais e Fitoterapia para cicatrização e doenças agudas. A partir de uma ampla busca bibliográfica foram incluídos no mapa 16 estudos de revisão sistemática. Todos os estudos foram avaliados, caracterizados e categorizados por um grupo de pesquisadores do Laboratório de Pesquisa & Desenvolvimento de Práticas Integrativas e Complementares (LabPICs) da Faculdade de Farmácia da Universidade Federal do Rio de Janeiro.

El mapa presenta una visión general de la evidencia sobre los efectos de las plantas medicinales y la fitoterapia para cicatrización y las enfermedades agudas. A partir de una amplia búsqueda bibliográfica, se incluyeron 16 estudios de revisión sistemática en el mapa. Todos los estudios fueron evaluados, caracterizados y categorizados por un grupo de investigadores del Laboratorio de Investigación y Desarrollo para Prácticas Integrativas y Complementarias (LabPIC) en la Facultad de Farmacia de la Universidad Federal de Rio de Janeiro.

The map presents an overview of the evidence on the effects of Medicinal Plants and Phytotherapy for for wound healing and acute diseases. From a wide bibliographic search, 16 systematic review studies were included in the map. All studies were evaluated, characterized and categorized by a group of researchers from the Research & Development Laboratory for Integrative and Complementary Practices (LabPICs) at the Faculty of Pharmacy, Federal University of Rio de Janeiro.

Mapa de Evidência: efetividade clínica das Plantas Medicinais e Fitoterapia para Doenças Crônicas e Dor / Mapa de Evidencia: efetividad clínica de las Plantas Medicinales y Fitoterapia para Enfermedades Cronicas y Dolor / Evidence Map: clinical effectiveness of Medicinal Plants and Phytotherapy for Chronic Diseases and Pain

O mapa apresenta uma visão geral das evidências sobre os efeitos das Plantas Medicinais e Fitoterapia para dor e doenças crônicas. A partir de uma ampla busca bibliográfica foram incluídos no mapa 49 estudos de revisão sistemática. Todos os estudos foram avaliados, caracterizados e categorizados por um grupo de pesquisadores do Laboratório de Pesquisa & Desenvolvimento de Práticas Integrativas e Complementares (LabPICs) da Faculdade de Farmácia da Universidade Federal do Rio de Janeiro.

El mapa presenta una visión general de la evidencia sobre los efectos de las plantas medicinales y la fitoterapia para el dolor y las enfermedades crónicas. A partir de una amplia búsqueda bibliográfica, se incluyeron 49 estudios de revisión sistemática en el mapa. Todos los estudios fueron evaluados, caracterizados y categorizados por un grupo de investigadores del Laboratorio de Investigación y Desarrollo para Prácticas Integrativas y Complementarias (LabPIC) en la Facultad de Farmacia de la Universidad Federal de Rio de Janeiro.

The map presents an overview of the evidence on the effects of Medicinal Plants and Phytotherapy for pain and chronic diseases. From a wide bibliographic search, 49 systematic review studies were included in the map. All studies were evaluated, characterized and categorized by a group of researchers from the Research & Development Laboratory for Integrative and Complementary Practices (LabPICs) at the Faculty of Pharmacy, Federal University of Rio de Janeiro.

Mapa de Evidência: efetividade clínica das Plantas Medicinais e Fitoterapia para Saúde Mental e Qualidade de Vida / Mapa de Evidencia: efetividad clínica de las Plantas Medicinales y Fitoterapia para Salud Mental y Calidad de Vida / Evidence Map: clinical effectiveness of Medicinal Plants and Phytotherapy for Mental Health and Quality of Life

O mapa apresenta uma visão geral das evidências sobre os efeitos das Plantas Medicinais e Fitoterapia para Saúde Mental e Qualidade de Vida. A partir de uma ampla busca bibliográfica foram incluídos no mapa 37 estudos de revisão sistemática. Todos os estudos foram avaliados, caracterizados e categorizados por um grupo de pesquisadores do Laboratório de Pesquisa & Desenvolvimento de Práticas Integrativas e Complementares (LabPICs) da Faculdade de Farmácia da Universidade Federal do Rio de Janeiro.

El mapa presenta una visión general de la evidencia sobre los efectos de las plantas medicinales y la fitoterapia para ela salud mental y calidad de vida. A partir de una amplia búsqueda bibliográfica, se incluyeron 37 estudios de revisión sistemática en el mapa. Todos los estudios fueron evaluados, caracterizados y categorizados por un grupo de investigadores del Laboratorio de Investigación y Desarrollo para Prácticas Integrativas y Complementarias (LabPIC) en la Facultad de Farmacia de la Universidad Federal de Rio de Janeiro.

The map presents an overview of the evidence on the effects of Medicinal Plants and Phytotherapy for mental health and quality of life. From a wide bibliographic search, 37 systematic review studies were included in the map. All studies were evaluated, characterized and categorized by a group of researchers from the Research & Development Laboratory for Integrative and Complementary Practices (LabPICs) at the Faculty of Pharmacy, Federal University of Rio de Janeiro.

Mapa de Evidência: efetividade clínica das Plantas Medicinais e Fitoterapia para Distúrbios Metabólicos e Fisiológicos / Mapa de Evidencia: efetividad clínica de las Plantas Medicinales y Fitoterapia para Trastornos Metabólicos y Fisiológicos Clinical / Evidence Map: effectiveness of Medicinal Plants and Phytotherapy for Metabolism and Physiological Disorders

O mapa apresenta uma visão geral das evidências sobre os efeitos das Plantas Medicinais e Fitoterapia para Distúrbios Metabólicos e Fisiológicos. A partir de uma ampla busca bibliográfica foram incluídos no mapa 48 estudos de revisão sistemática. Todos os estudos foram avaliados, caracterizados e categorizados por um grupo de pesquisadores do Laboratório de Pesquisa & Desenvolvimento de Práticas Integrativas e Complementares (LabPICs) da Faculdade de Farmácia da Universidade Federal do Rio de Janeiro.

El mapa presenta una visión general de la evidencia sobre los efectos de las plantas medicinales y la fitoterapia para el trastornos metabólicos y fisiológicos. A partir de una amplia búsqueda bibliográfica, se incluyeron 48 estudios de revisión sistemática en el mapa. Todos los estudios fueron evaluados, caracterizados y categorizados por un grupo de investigadores del Laboratorio de Investigación y Desarrollo para Prácticas Integrativas y Complementarias (LabPIC) en la Facultad de Farmacia de la Universidad Federal de Rio de Janeiro.

The map presents an overview of the evidence on the effects of Medicinal Plants and Phytotherapy for Metabolic and Physiological Disorders. From a wide bibliographic search, 48 systematic review studies were included in the map. All studies were evaluated, characterized and categorized by a group of researchers from the Research & Development Laboratory for Integrative and Complementary Practices (LabPICs) at the Faculty of Pharmacy, Federal University of Rio de Janeiro.